Profile
Single-molecule bio-physicist with hard skills in optics and microscopy.
I am fascinated by how complex and tightly regulated processes governing biological systems emerge from the interaction of molecular constituents subjected to stochastic behaviour. The purpose of my research activity is to gain insight into the interplay of the physical and biological mechanisms that shape and govern living cells. To this end, I develop and apply advanced imaging tools to visualize and quantify in situ dynamical processes and biochemical reactions in vitro and in single cells, at the single-molecule level. My current work is primarily focused on the study of protein-DNA transactions in transcription and gene expression regulation and in DNA repair and genome integrity maintenance. In particular, I am interested in assessing the role of nuclear factors mobility, genome organization, DNA topology, and their interrelationship in orchestrating nuclear processes plasticity.
I am fascinated by how complex and tightly regulated processes governing biological systems emerge from the interaction of molecular constituents subjected to stochastic behaviour. The purpose of my research activity is to gain insight into the interplay of the physical and biological mechanisms that shape and govern living cells. To this end, I develop and apply advanced imaging tools to visualize and quantify in situ dynamical processes and biochemical reactions in vitro and in single cells, at the single-molecule level. My current work is primarily focused on the study of protein-DNA transactions in transcription and gene expression regulation and in DNA repair and genome integrity maintenance. In particular, I am interested in assessing the role of nuclear factors mobility, genome organization, DNA topology, and their interrelationship in orchestrating nuclear processes plasticity.
