Scientific interests
Le trait d'union of my scientific research is the application of state-of-the-art optical and physical techniques to unravel cellular regulation mechanisms at the single-molecule level. I am particularly interested in transcription regulation and in the interplay between nuclear factors mobility, genome organization, and DNA topology in orchestrating gene expression plasticity. Currently, I work on a project dedicated to study the target search mechanisms of individual DNA-binding proteins in human cells. In my future researches, I want to encompass the study of endogenous biochemical reactions and to investigate how complex molecular machinery are recruited and assembled at specific sites on the genome, in living cells. Also, I am very interested in understanding how the “linear” and the “three dimensional” organization of genes in functional territories as well as in different chemical and physical environments influences the nuclear processes.
Research projects
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